A Quick Method to Assess Airway Distensibility in Mice.

ABSTRACT: Airway distensibility is defined as the ease whereby airways are dilating in response to inflating lung pressure. If measured swiftly and accurately, airway distensibility would be a useful readout to parse the various elements contributing to airway wall stiffening, such as smooth muscle contraction, surface tension, and airway remodeling. The goal of the present study was to develop a method for measuring airway distensibility in mice. Lungs of BALB/c and C57BL/6 mice from either sex were subjected to stepwise changes in pressure. At each pressure step, an oscillometric perturbation was used to measure the impedance spectrum, on which the constant-phase model was fitted to deduce a surrogate for airway caliber called Newtonian conductance (G_N). The change in G_N over

SUBMITTER: Gill R 

PROVIDER: S-EPMC11247055 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature