Pareto optimization of SPECT acquisition and reconstruction settings for ¹⁷⁷Lu activity quantification.

ABSTRACT:

Background

The aim was to investigate the noise and bias properties of quantitative ¹⁷⁷Lu-SPECT with respect to the number of projection angles, and the number of subsets and iterations in the OS-EM reconstruction, for different total acquisition times.

Methods

Experimental SPECT acquisition of six spheres in a NEMA body phantom filled with ¹⁷⁷Lu was performed, using medium-energy collimators and 120 projections with 180 s per projection. Bootstrapping was applied to generate data sets representing acquisitions with 20 to 120 projections for 10 min, 20 min, and 40 min, with 32 noise realizations per setting. Monte Carlo simulations were performed of ¹⁷⁷Lu-DOTA-TATE in an anthropomorphic computer phantom with three tumours (2.8 mL to 40.0 mL).

SUBMITTER: Gustafsson J 

PROVIDER: S-EPMC11247071 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature