Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia.

ABSTRACT: Previous studies that focused on univariate correlations between neuroanatomy and cognition in schizophrenia identified some inconsistent findings. Moreover, antipsychotic medication may impact the brain-behavior profiles in affected individuals. It remains unclear whether unmedicated and medicated individuals with schizophrenia would share common neuroanatomy-cognition associations. Therefore, we aimed to investigate multivariate neuroanatomy-cognition relationships in both groups. A sample of 59 drug-naïve individuals with first-episode schizophrenia (FES) and a sample of 115 antipsychotic-treated individuals with schizophrenia were finally included. Multivariate modeling was conducted in the two patient samples between multiple cognitive domains and neuroanatomic features, such as corti

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11247086 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature