Quantification of circadian rhythms in mammalian lung tissue snapshot data.

ABSTRACT: Healthy mammalian cells have a circadian clock, a gene regulatory network that allows them to schedule their physiological processes to optimal times of the day. When healthy cells turn into cancer cells, the circadian clock often becomes cancer specifically disturbed, so there is an interest in the extraction of circadian features from gene expression data of cancer. This is challenging, as clinical gene expression samples of cancer are snapshot-like and the circadian clock is best examined using gene expression time series. In this study, we obtained lists of intersecting circadian genes in public gene expression time series data of lung tissue of mouse and baboon. We base our circadian gene lists on correlations of gene expression levels of circadian genes, which are closely associated

SUBMITTER: Grabe S 

PROVIDER: S-EPMC11247089 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature