Cognitive impairment in children and adolescents living with perinatal HIV disease in the ART era: a meta-analysis.

ABSTRACT:

Background

Despite improved survival and overall health outcomes from modern antiretroviral therapy (ART), children and adolescents living with HIV are facing pervasive impairments in neurodevelopment including cognitive impairment, but there remains a lack of consensus on the cognitive domains that are affected in those children and adolescents. The objective of this meta-analysis was to evaluate the impact of perinatal HIV-infection on executive function, working memory, and speed of information processing in the ART era.

Methods

The PubMed database was searched for studies published between 1997 and 2024, plus additional search with the ScienceDirect, bioRxiv, and medRxiv databases. A meta-analysis was conducted on thirty-five studies published between 2012 and 2023 that

SUBMITTER: Dahmani S 

PROVIDER: S-EPMC11247155 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature