Beta-blocker initiation under dobutamine infusion in acute advanced heart failure: a target trial emulation with observational data.

ABSTRACT:

Aims

In patients with advanced heart failure requiring dobutamine infusion, it is usually recommended to initiate beta-blockers after weaning from dobutamine. However, beta-blockers are sometimes initiated under dobutamine infusion in a real-world scenario. The association between such early beta-blocker initiation with clinical outcomes is unknown. Therefore, this study investigates the association between initiating beta-blockers under dobutamine infusion and survival outcomes.

Methods and results

This observational study with a multicentre inpatient-care database emulated a pragmatic randomized controlled trial (RCT) of the beta-blocker initiation strategy. First, 1151 patients on dobutamine and not on beta-blockers on the day of heart failure admission (Day 0) were ident

SUBMITTER: Mori Y 

PROVIDER: S-EPMC11247169 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature