Analyzing microbial evolution through gene and genome phylogenies.

ABSTRACT: Microbiome scientists critically need modern tools to explore and analyze microbial evolution. Often this involves studying the evolution of microbial genomes as a whole. However, different genes in a single genome can be subject to different evolutionary pressures, which can result in distinct gene-level evolutionary histories. To address this challenge, we propose to treat estimated gene-level phylogenies as data objects, and present an interactive method for the analysis of a collection of gene phylogenies. We use a local linear approximation of phylogenetic tree space to visualize estimated gene trees as points in low-dimensional Euclidean space, and address important practical limitations of existing related approaches, allowing an intuitive visualization of complex data objects. We d

SUBMITTER: Teichman S 

PROVIDER: S-EPMC11247178 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature