Effects of high dose aspartame-based sweetener on the gut microbiota and bone strength in young and aged mice.

ABSTRACT: In a recent study examining the effects of manipulating the gut microbiome on bone, a control group of mice in which the microbiome was altered using a non-caloric, aspartame-based sweetener resulted in whole bone strength being 40% greater than expected from geometry alone, implicating enhanced bone tissue strength. However, the study was not designed to detect changes in bone in this control group and was limited to young male mice. Here we report a replication study examining how changes in the gut microbiome caused by aspartame-based sweetener influence bone. Male and female C57Bl/6 J mice were untreated or treated with a high dose of sweetener (10 g/L) in their drinking water from either 1 to 4 mo of age (young cohort; n = 80) or 1 to 22 mo of age (aged cohort; n = 52).

SUBMITTER: Cyphert EL 

PROVIDER: S-EPMC11247189 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature