The FinO/ProQ-like protein PA2582 impacts antimicrobial resistance in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Bacteria employ small regulatory RNAs (sRNA) and/or RNA binding proteins (RBPs) to respond to environmental cues. In Enterobacteriaceae, the FinO-domain containing RBP ProQ associates with numerous sRNAs and mRNAs, impacts sRNA-mediated riboregulation or mRNA stability by binding to 5'- or 3'-untranslated regions as well as to internal stem loop structures. Global RNA-protein interaction studies and sequence comparisons identified a ProQ-like homolog (PA2582/ProQ _Pae ) in Pseudomonas aeruginosa (Pae). To address the function of ProQ _Pae , at first a comparative transcriptome analysis of the Pae strains PAO1 and PAO1ΔproQ was performed. This study revealed more than 100 differentially abundant transcripts, affecting a va

SUBMITTER: Cianciulli Sesso A 

PROVIDER: S-EPMC11247311 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature