Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges.

ABSTRACT:

Background

The Neonatal Oxygenation Prospective Meta-analysis found that in infants <28 weeks gestational age, targeting an oxygen saturation (S _pO2 ) range of 85-89% versus 91-95% resulted in lower rates of retinopathy of prematurity but increased mortality. We aimed to evaluate the accuracy of the heart rate characteristics index (HRCi) in assessing the dynamic risk of mortality among infants managed with low and high target S _pO2 ranges.

Methods

We linked the SUPPORT and HRCi datasets from one centre in which the randomised controlled trials overlapped. We examined the maximum daily HRCi (MaxHRCi24) to predict mortality among patients randomised to the lower and higher target S _pO2

SUBMITTER: King WE 

PROVIDER: S-EPMC11247370 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature