Low progesterone receptor levels in high-grade DCIS correlate with HER2 upregulation and the presence of invasive components.

ABSTRACT:

Objective

In this study, we investigated pivotal molecular markers in human high-grade breast ductal carcinoma in situ (DCIS). Expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth receptor 2 (HER2) was measured among various subtypes (Luminal (Lum) A, LumB HER2^-, LumB HER2⁺, HER2-enriched and triple-negative).

Methods

In total, 357 DCIS cases were classified into respective subtypes, according to the 2013 St. Gallen guidelines. Each subtype was categorized into three subcategories: "Pure" (those without an invasive component), "W/invasive" (those with an invasive component), and "All" (the entire group of the given subtype). ER and PR expression were registered as intervals. Equivocal HER2 immunohist

SUBMITTER: Schandiz H 

PROVIDER: S-EPMC11247389 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature