Revealing the novel metabolism-related genes in the ossification of the ligamentum flavum based on whole transcriptomic data.

ABSTRACT:

Backgrounds

The ossification of the ligamentum flavum (OLF) is one of the major causes of thoracic myelopathy. Previous studies indicated there might be a potential link between metabolic disorder and pathogenesis of OLF. The aim of this study was to determine the potential role of metabolic disorder in the pathogenesis of OLF using the strict bioinformatic workflow for metabolism-related genes and experimental validation.

Methods

A series of bioinformatic approaches based on metabolism-related genes were conducted to compare the metabolism score between OLF tissues and normal ligamentum flavum (LF) tissues using the single sample gene set enrichment analysis. The OLF-related and metabolism-related differentially expressed genes (OMDEGs) were screened out, and the biological

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11247397 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature