Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study.

ABSTRACT: Predicting long-term kidney allograft failure is an unmet need for clinical care and clinical trial optimization in children. We aimed to validate a kidney allograft failure risk prediction system in a large international cohort of pediatric kidney transplant recipients. Patients from 20 centers in Europe and the United States, transplanted between 2004 and 2017, were included. Allograft assessment included estimated glomerular filtration rate, urine protein-to-creatinine ratio, circulating antihuman leukocyte antigen donor-specific antibody, and kidney allograft histology. Individual predictions of allograft failure were calculated using the integrative box (iBox) system. Prediction performances were assessed using discrimination and calibration. The allograft evaluations were performed i

SUBMITTER: Hogan J 

PROVIDER: S-EPMC11247401 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature