WTAP promotes proliferation of esophageal squamous cell carcinoma via m⁶A-dependent epigenetic promoting of PTP4A1.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) represents a frequently seen malignancy with high prevalence worldwide. Although current studies have shown that Wilms' tumor 1-associated protein (WTAP), a major part in the methyltransferase complex, is involved in various tumor pathological processes, its specific role in ESCC remains unclear. Therefore, the present work focused on exploring WTAP's function and mechanism in ESCC progression using clinical ESCC specimens, ESCC cells, and mammalian models. Firstly, we proved WTAP was significantly upregulated within ESCC, and WTAP mRNA expression showed a good diagnostic performance for ESCC. Functionally, WTAP positively regulated in-vivo and in-vitro ESCC cells' malignant phenotype through the AKT-mTOR signaling pathway. Meanwhile, WTAP positive

SUBMITTER: Zou J 

PROVIDER: S-EPMC11247548 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature