Gray matter volume mediates the association of long-term blood pressure variability with cognitive function in an adult population.

ABSTRACT:

Introduction

We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function.

Methods

We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020. Brain magnetic resonance imaging (MRI) and Montreal Cognitive Assessment (MoCA) were conducted in 2020.

Results

Higher systolic BPV (SBPV) and diastolic BPV (DBPV) were associated with lower total and frontal gray matter (GM) volume, and higher SBPV was associated with lower temporal GM volume. Elevated DBPV was associated with lower volume of total brain and parietal GM, and higher white matter hyperintensity (WMH) volume. Higher SBPV and DBPV were associated with lower MoCA scores. Decreased total and regional GM volume and incre

SUBMITTER: Li X 

PROVIDER: S-EPMC11247661 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature