Concurrent nutrient deficiencies are associated with dementia incidence.

ABSTRACT:

Introduction

While observational research suggests a protective role for nutrition in brain aging, intervention studies remain inconclusive. This failing translation from observational to interventional research may result from overlooking nutrient interactions.

Methods

We developed a nutrient status index capturing the number of suboptimal statuses of omega-3 fatty acids, homocysteine, and vitamin D (range 0 to 3). We associated this index with dementia incidence in a subsample (age ≥ 50 years) of the Framingham Heart Study Offspring cohort.

Results

Among 968 participants, 79 developed dementia over 15.5 years (median follow-up). Each point increase in nutrient status index was associated with a 50% higher risk of dementia (hazard ratio [HR] = 1.50; 95% confidence in

SUBMITTER: van Soest APM 

PROVIDER: S-EPMC11247665 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature