Diabetes accelerates Alzheimer's disease progression in the first year post mild cognitive impairment diagnosis.

ABSTRACT:

Background

Mild cognitive impairment (MCI) heightens Alzheimer's disease (AD) risk, with diabetes mellitus (DM) potentially exacerbating this vulnerability. This study identifies the optimal intervention period and neurobiological targets in MCI to AD progression using the Alzheimer's Disease Neuroimaging Initiative dataset.

Methods

Analysis of 980 MCI patients, categorized by DM status, used propensity score matching and inverse probability treatment weighting to assess rate of conversion from MCI to AD, neuroimaging, and cognitive changes.

Results

DM significantly correlates with cognitive decline and an increased risk of progressing to AD, especially within the first year of MCI follow-up. It adversely affects specific brain structures, notably accelerating nucleus

SUBMITTER: Ding X 

PROVIDER: S-EPMC11247667 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature