Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study.

ABSTRACT:

Introduction

Cognitive reserve might mitigate the risk of Alzheimer's dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation.

Methods

We examined cross-sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD-related biomarkers among 113 memory clinic patients. The longitudinal association between CRI and cognition over a 3-year follow-up was assessed. We examined whether associations were influenced by perceived stress and five measures of diurnal salivary cortisol.

Results

Higher CRI scores were associated with better cognition. Adjusting for cortisol measures reduced the beneficial

SUBMITTER: Yerramalla MS 

PROVIDER: S-EPMC11247673 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature