Serum NfL and GFAP as biomarkers of progressive neurodegeneration in TBI.

ABSTRACT:

Background

We examined spatial patterns of brain atrophy after mild, moderate, and severe traumatic brain injury (TBI), the relationship between progression of brain atrophy with initial traumatic axonal injury (TAI), cognitive outcome, and with serum biomarkers of brain injury.

Methods

A total of 143 patients with TBI and 43 controls were studied cross-sectionally and longitudinally up to 5 years with multiple assessments, which included brain magnetic resonance imaging, cognitive testing, and serum biomarkers.

Results

TBI patients showed progressive volume loss regardless of injury severity over several years, and TAI was independently associated with accelerated brain atrophy. Cognitive performance improved over time. Higher baseline serum neurofilament light (NfL)

SUBMITTER: Shahim P 

PROVIDER: S-EPMC11247683 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature