Entorhinal vessel density correlates with phosphorylated tau and TDP-43 pathology.

ABSTRACT:

Introduction

The entorhinal cortex (EC) and perirhinal cortex (PC) are vulnerable to Alzheimer's disease. A triggering factor may be the interaction of vascular dysfunction and tau pathology.

Methods

We imaged post mortem human tissue at 100 μm³ with 7 T magnetic resonance imaging and manually labeled individual blood vessels (mean = 270 slices/case). Vessel density was quantified and compared per EC subfield, between EC and PC, and in relation to tau and TAR DNA-binding protein 43 (TDP-43) semiquantitative scores.

Results

PC was more vascularized than EC and vessel densities were higher in posterior EC subfields. Tau and TDP-43 strongly correlated with vasculature density and subregions with severe tau at the preclinical stage had significantly greater ves

SUBMITTER: Llamas Rodriguez J 

PROVIDER: S-EPMC11247684 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature