Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America.

ABSTRACT:

Introduction

Leveraging the nonmonolithic structure of Latin America, which represents a large variability in social determinants of health (SDoH) and high levels of genetic admixture, we aim to evaluate the relative contributions of SDoH and genetic ancestry in predicting dementia prevalence in Latin American populations.

Methods

Community-dwelling participants aged 65 and older (N = 3808) from Cuba, Dominican Republic, Mexico, and Peru completed the 10/66 protocol assessments. Dementia was diagnosed using the cross-culturally validated 10/66 algorithm. Multivariate linear regression models adjusted for SDoH were used in the main analysis. This study used cross-sectional data from the 1066 population-based study.

Results

Individuals with higher proportions of Native

SUBMITTER: Llibre-Guerra JJ 

PROVIDER: S-EPMC11247688 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature