Development of a prediction model for cognitive impairment of sarcopenia using multimodal neuroimaging in non-demented older adults.

ABSTRACT:

Introduction

Despite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking.

Methods

We used data from 528 non-demented older adults with or without sarcopenia in the Catholic Aging Brain Imaging (CABI) database, containing magnetic resonance imaging scans, positron emission tomography scans, and clinical data. We also measured three key components of sarcopenia: skeletal muscle index (SMI), hand grip strength (HGS), and the five times sit-to-stand test (5STS).

Results

All components of sarcopenia were significantly correlated with global cognitive function, but cortical thickness and amyloid-beta (Aβ) retention had distinctive relationships with eac

SUBMITTER: Kim S 

PROVIDER: S-EPMC11247690 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature