Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease.

ABSTRACT:

Introduction

Female-specific reproductive factors and exogeneous estrogen use are associated with cognition in later life. However, the underlying mechanisms are not understood. The present study aimed to investigate the effect of reproductive factors on neuroimaging biomarkers of Alzheimer's disease (AD) and cerebrovascular pathologies.

Methods

We evaluated 389 females (median age of 71.7 years) enrolled in the Mayo Clinic Study of Aging with reproductive history data and longitudinal magnetic resonance imaging (MRI) scans. We used linear mixed effect models to examine the associations between reproductive factors and changes in neuroimaging measures.

Results

Ever hormonal contraception (HC) use was longitudinally associated with higher fractional anisotropy across t

SUBMITTER: Lee JK 

PROVIDER: S-EPMC11247693 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature