Patterns of cognitive domain abnormalities enhance discrimination of dementia risk prediction: The ARIC study.

ABSTRACT:

Introduction

The contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated.

Methods

We analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities (ARIC) study. We examined associations of index domain-specific neuropsychological test performance with incident dementia using cumulative incidence curves and Cox proportional hazards models.

Results

Among 5296 initially dementia-free participants (mean [standard deviation] age of 75.8 [5.1] years; 60.1% women, 22.2% Black) over a median follow-up of 7.9 years, the covariate-adjusted hazard ratio varied substantially depending on the pattern of domain-specific performance and age, in an orderly manner from single dom

SUBMITTER: Knopman DS 

PROVIDER: S-EPMC11247695 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature