Association of cognitive reserve with transitions across cognitive states and death in older adults: A 15-year follow-up study.

ABSTRACT:

Introduction

We investigated the association of cognitive reserve (CR) with transitions across cognitive states and death.

Methods

This population-based cohort study included 2631 participants (age ≥60 years) who were dementia-free at baseline and regularly examined up to 15 years. Data were analyzed using the Markov multistate models.

Results

Each 1-point increase in the composite CR score (range: -4.25 to 3.46) was significantly associated with lower risks of transition from normal cognition to cognitive impairment, no dementia (CIND) (multivariable-adjusted hazards ratio = 0.78; 95% confidence interval = 0.72-0.85) and death (0.85; 0.79-0.93), and from CIND to death (0.82; 0.73-0.91), but not from CIND to normal cognition or dementia. A greater composite CR score w

SUBMITTER: Li Y 

PROVIDER: S-EPMC11247709 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature