Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats.

ABSTRACT:

Background

Episodes of recurrent or severe hypoglycemia can occur in patients with diabetes mellitus, insulinoma, neonatal hypoglycemia, and medication errors. However, little is known about the short-term and long-term effects of repeated episodes of acute severe hypoglycemia on the brain, particularly in relation to hippocampal damage and cognitive dysfunction.

Methods

Thirty-six wistar rats were randomly assigned to either the experimental or control group. The rats were exposed to severe hypoglycemia, and assessments were conducted to evaluate oxidative stress in brain tissue, cognitive function using the Morris water maze test, as well as histopathology and immunohistochemistry studies. The clinical and histopathological evaluations were conducted in the short-term and

SUBMITTER: Nikpendar M 

PROVIDER: S-EPMC11247731 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature