Impact of once-daily versus multiple-daily dosing of gentamicin on the incidence of acute kidney injury in patients treated with synergistic combinations of antibiotics.

ABSTRACT:

Background

Gentamicin is a commonly used antibiotic with synergistic effects that is administered once or multiple times daily. However, the influence of the daily administration frequency on renal function has not yet been identified. This study aimed to investigate the effect of the daily dosing frequency on worsening renal function in patients receiving gentamicin.

Methods

This study included 35 patients undergoing gentamicin treatment who had at least one serum trough level measured and underwent therapeutic drug monitoring (TDM). We evaluated the influence of daily dosing frequency on gentamicin trough concentration and the risk of acute kidney injury (AKI).

Results

Compared to patients who received gentamicin once-daily dosing (n = 22), patients who received mul

SUBMITTER: Sugiyama K 

PROVIDER: S-EPMC11247752 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature