Endometrial senescence is mediated by interleukin 17 receptor B signaling.

ABSTRACT:

Background

We previously identified Il17RB, a member of the IL17 superfamily, as a candidate marker gene for endometrial aging. While IL17RB has been linked to inflammation and malignancies in several organ systems, its function in the endometrium has not been investigated and is thus poorly understood. In the present study, we performed a functional analysis of this receptor with the aim of determining the effects of its age-associated overexpression on the uterine environment.

Methods

We analyzed IL17RB-related signaling pathways and downstream gene expression in an immortalized human endometrial glandular epithelial cell line ("hEM") forced to express the receptor via lentiviral transduction ("IL17RB-hEM"). We also prepared endometrial organoids from human endometrial tis

SUBMITTER: Kawamura K 

PROVIDER: S-EPMC11247761 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature