Associations between quantitative measures of mammographic density and terminal ductal lobular unit involution in Chinese breast cancer patients.

ABSTRACT:

Background

Higher mammographic density (MD), a radiological measure of the proportion of fibroglandular tissue in the breast, and lower terminal duct lobular unit (TDLU) involution, a histological measure of the amount of epithelial tissue in the breast, are independent breast cancer risk factors. Previous studies among predominantly white women have associated reduced TDLU involution with higher MD.

Methods

In this cohort of 611 invasive breast cancer patients (ages 23-91 years [58.4% ≥ 50 years]) from China, where breast cancer incidence rates are lower and the prevalence of dense breasts is higher compared with Western countries, we examined the associations between TDLU involution assessed in tumor-adjacent normal breast tissue and quantitative MD assessed in the contral

SUBMITTER: Mburu W 

PROVIDER: S-EPMC11247848 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature