Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes.

ABSTRACT:

Background

The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of cancer have revealed many germline risk factors associated with cancer. However, the overlap between known somatic driver genes and positional candidate genes from GWAS loci is surprisingly small. We hypothesised that genes from multiple independent cancer GWAS loci should show tissue-specific co-regulation patterns that converge on cancer-specific driver genes.

Results

We studied recent well-powered GWAS of breast, prostate, colorectal and skin cancer by estimating co-expression between genes and subsequently prioritising genes that show significant co-expression wit

SUBMITTER: Urzua-Traslavina CG 

PROVIDER: S-EPMC11247850 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature