Assessment of glycemic susceptibility across multiple urological and reproductive disorders.

ABSTRACT:

Objective

To test the glycemic susceptibility in three urological cancers and eight urological/reproductive diseases using the Mendelian randomization (MR) method.

Materials and methods

Two-sample MR was applied to investigate the causal role of three glycemic traits (type II diabetes, fasting glucose and glycated hemoglobin (HbA1c)) in eleven urological/reproductive diseases (kidney cancer, bladder cancer, prostate cancer, kidney/ureter stone, urinary incontinence, benign prostatic hyperplasia, erectile dysfunction, female infertility, male infertility, abnormal spermatozoa and polycystic ovary syndrome). Further multivariate MR (MVMR) and mediating analysis were performed to investigate the associations.

Results

Among all the 11 diseases, type II diabetes was positi

SUBMITTER: Zeng X 

PROVIDER: S-EPMC11247903 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature