Two common and distinct forms of variation in human functional brain networks.

ABSTRACT: The cortex has a characteristic layout with specialized functional areas forming distributed large-scale networks. However, substantial work shows striking variation in this organization across people, which relates to differences in behavior. While most previous work treats individual differences as linked to boundary shifts between the borders of regions, here we show that cortical 'variants' also occur at a distance from their typical position, forming ectopic intrusions. Both 'border' and 'ectopic' variants are common across individuals, but differ in their location, network associations, properties of subgroups of individuals, activations during tasks, and prediction of behavioral phenotypes. Border variants also track significantly more with shared genetics than ectopic variants, sug

SUBMITTER: Dworetsky A 

PROVIDER: S-EPMC11248096 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature