Whole-brain radiation therapy plus simultaneous integrated boost for brain metastases from breast cancers.

ABSTRACT:

Background

The effect of whole-brain radiation therapy (WBRT) plus simultaneous integrated boost (SIB) in brain metastasis from breast cancers has not been demonstrated.

Method

In this single-center retrospective study, we reviewed consecutive breast cancer patients who developed brain metastasis and were treated with hypofractionated radiation therapy plus WBRT using intensity-modulated radiation therapy (IMRT)-SIB approaches. We analyzed clinical outcomes, prognostic factors and patterns of treatment failure.

Result

A total of 27 patients were eligible for analysis. Four (14.8%) patients achieved clinical complete response and 14 (51.9%) had partial response of brain lesions. The other nine patients were not evaluated for brain tumor response. The median brain progr

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11248998 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature