A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.

ABSTRACT: Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by ac

SUBMITTER: Methi A 

PROVIDER: S-EPMC11249425 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature