Cancer of Unknown Primary: When Imaging, Pathology, and Molecular Biology Do Not Match.

ABSTRACT:

Introduction

Cancers of unknown primary are aggressive and rare malignancies with a complex diagnosis and management. Here we present a case in which imaging, pathology, and molecular biology did not match for a specific tumor site and the importance of a multidisciplinary team for these complicated cases.

Case presentation

A man in his 70s with strong smoking history under workup for suspicion of metastatic lung cancer underwent lung mass biopsy. Immunohistochemical stains corresponded to hepatocellular/cholangiocarcinoma or germ cell tumor; however, dedicated liver and testicular studies including imaging and iscochrome 12p FISH were negative. Additionally, somatic variant profiling was not specific for any malignancy nor targetable variants. Given the pattern of disease,

SUBMITTER: Juarez-Vignon Whaley JJ 

PROVIDER: S-EPMC11249445 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature