Identification of a gene expression signature associated with brain metastasis in colorectal cancer.

ABSTRACT:

Purpose

Brain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung and bone metastasis no biomarkers exist to identify patients at risk. This study aimed to identify a gene expression signature associated with colorectal BM.

Methods

Three patient groups were formed: 1. CRC with brain metastasis (BRA), 2. exclusive liver metastasis (HEP) and, 3. non-metastatic disease (M0). RNA was extracted from primary tumors and mRNA expression was measured using a NanoString Panel (770 genes). Expression was confirmed by qPCR in a validation cohort. Statistical analyses including multivariate logistic regression followed by receiver operating characteristic (ROC) analysis were performed.

Results

EMILIN3, MTA1, SV2B, TMPRS

SUBMITTER: Michl M 

PROVIDER: S-EPMC11249597 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature