Quantifying tissue temperature changes induced by infrared neural stimulation: numerical simulation and MR thermometry.

ABSTRACT: Infrared neural stimulation (INS) delivered via short pulse trains is an innovative tool that has potential for us use for studying brain function and circuitry, brain machine interface, and clinical use. The prevailing mechanism for INS involves the conversion of light energy into thermal transients, leading to neuronal membrane depolarization. Due to the potential risks of thermal damage, it is crucial to ensure that the resulting local temperature increases are within non-damaging limits for brain tissues. Previous studies have estimated damage thresholds using histological methods and have modeled thermal effects based on peripheral nerves. However, additional quantitative measurements and modeling studies are needed for the central nervous system. Here, we performed 7 T MRI thermometr

SUBMITTER: Xi Y 

PROVIDER: S-EPMC11249695 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature