Efficacy of lysostaphin-coated titanium plates on implant-associated MRSA osteitis in minipigs.

ABSTRACT:

Purpose

The growing incidence of implant-associated infections (IAIs) caused by biofilm-forming Staphylococcus aureus in combination with an increasing resistance to antibiotics requires new therapeutic strategies. Lysostaphin has been shown to eliminate this biofilm. Own studies confirm the effectiveness in a murine model. The current study characterizes the effects of lysostaphin-coated plates in an IAI minipig model.

Methods

The femur of 30 minipigs was stabilized with a five-hole plate, a bone defect was created, and in 20 cases methicillin-resistant Staphylococcus aureus was applied. Ten animals served as control group. After 14 days, local debridement, lavage, and plate exchange (seven-hole plate) were performed. Ten of the infected minipigs received an uncoated plate

SUBMITTER: Jaekel C 

PROVIDER: S-EPMC11249774 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature