High baseline perivascular space volume in basal ganglia is associated with attention and executive function decline in Parkinson's disease.

ABSTRACT:

Background

Pathologic perivascular spaces (PVS), the fluid-filled compartments surrounding brain vasculature, may underlie cognitive decline in Parkinson's disease (PD). However, whether this impacts specific cognitive domains has not been investigated.

Objectives

This study examined the relationship of PVS volume at baseline with domain-specific and global cognitive change over 2 years in PD individuals.

Methods

A total of 39 individuals with PD underwent 3T T1w magnetic resonance imaging to determine PVS volume fraction (PVS volume normalized to total regional volume) within (i) centrum semiovale, (ii) prefrontal white matter (medial orbitofrontal, rostral middle frontal, and superior frontal), and (iii) basal ganglia. A neuropsychological battery included assessmen

SUBMITTER: Foreman RP 

PROVIDER: S-EPMC11250171 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature