Heterogeneity of fibroblast activation protein expression in the microenvironment of an intracranial tumor cohort: head-to-head comparison of gallium-68 FAP inhibitor-04 (⁶⁸Ga-FAPi-04) and fluoride-18 fluoroethyl-L-tyrosine (¹⁸F-FET) in positron emission tomography-computed tomography imaging.

ABSTRACT:

Background

Cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) can interact with tumor parenchymal cells to promote tumor growth and migration. Fibroblast activation protein (FAP) expressed by CAFs can be targeted with positron emission tomography (PET) tracers, but studies on FAP expression patterns in intracranial tumors remain scarce. We aimed to evaluate FAP expression patterns in intracranial tumors with gallium-68 FAP inhibitor-04 (⁶⁸Ga-FAPi-04) and immunohistochemical staining and to observe the interactions between CAFs and tumor cells with a head-to-head comparison of ⁶⁸Ga-FAPi-04 and fluoride-18 fluoroethyl-L-tyrosine (¹⁸F-FET) for PET quantification analysis.

Methods

We prospectively enrolled 22 adult patie

SUBMITTER: Hua T 

PROVIDER: S-EPMC11250301 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature