The mechanism of bone metabolism in a Sprague Dawley rat model of mandibular osteoradionecrosis.

ABSTRACT:

Background

Osteoradionecrosis (ORN) is a serious complication of radiotherapy for head and neck cancer. There is currently a lack of data on the dynamic expression of genes related to bone remodeling during the development of mandibular ORN. This study aimed to establish an animal model of ORN in Sprague Dawley (SD) rats, detect the expression of genes related to bone metabolism, observe morphological changes, and clarify the mechanism of ORN.

Methods

A total of 24 male SD rats in group 1 were randomly divided into four groups (n=6/group): group a, normal control; group b, simple tooth extraction; group c, simple radiation; and group d, radiation extraction group. The right mandible of rats in groups c and d was irradiated with a single dose of 35 Gy. The right mandibles wer

SUBMITTER: Liu S 

PROVIDER: S-EPMC11250332 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature