Exploring the association between acute pancreatitis and biliary tract cancer: A large-scale population-based matched cohort study.

ABSTRACT:

Background

Biliary tract cancer (BTC) often goes undetected until its advanced stages, resulting in a poor prognosis. Given the anatomical closeness of the gallbladder and bile ducts to the pancreas, the inflammatory processes triggered by acute pancreatitis might increase the risk of BTC.

Objective

To assess the association between acute pancreatitis and the risk of BTC.

Methods

Using the Swedish Pancreatitis Cohort (SwePan), we compared the BTC risk in patients with a first-time episode of acute pancreatitis during 1990-2018 to a 1:10 matched pancreatitis-free control group. Multivariable Cox regression models, stratified by follow-up duration, were used to calculate hazard ratios (HRs), adjusting for socioeconomic factors, alcohol use, and comorbidities.

Results

SUBMITTER: Selin D 

PROVIDER: S-EPMC11250377 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature