Genomic evolution of ST228 SCCmec-I MRSA 10 years after a major nosocomial outbreak.

ABSTRACT: In this study, we investigated the genomic changes in a major methicillin-resistant Staphylococcus aureus (MRSA) clone following a significant outbreak at a hospital. Whole-genome sequencing of MRSA isolates was utilized to explore the genomic evolution of post-outbreak MRSA strains. The epidemicity of the clone declined over time, coinciding with the introduction of multimodal infection control measures. A genome-wide association study (GWAS) identified multiple genes significantly associated with either high or low epidemic success, indicating alterations in mobilome, virulence, and defense mechanisms. Random Forest models pinpointed a gene related to fibrinogen binding as the most influential predictor of epidemicity. The decline of the MRSA clone may be attributed to various fac

SUBMITTER: Mauffrey F 

PROVIDER: S-EPMC11250417 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature