Alterations in tryptophan metabolism and de novo NAD⁺ biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation.

ABSTRACT:

Background

Inflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by catalytic enzymes that affect the downstream metabolic pathways of de novo nicotinamide adenine dinucleotide (NAD⁺) synthesis. It is hypothesized that a correlation exists between tryptophan de novo NAD⁺ synthesis and chronic intestinal inflammation.

Methods

Transcriptome analysis was performed using high-throughput sequencing of mRNA extracted from the distal colon and brain tissue of Winnie mice with spontaneous chronic colitis and C57BL/6 littermates. Metabolites were assessed u

SUBMITTER: Devereaux J 

PROVIDER: S-EPMC11250461 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature