Lymphocytic colitis can be transcriptionally divided into channelopathic and inflammatory lymphocytic colitis.

ABSTRACT:

Background

The pathobiology of the non-destructive inflammatory bowel disease (IBD) lymphocytic colitis (LC) is poorly understood. We aimed to define an LC-specific mucosal transcriptome to gain insight into LC pathology, identify unique genomic signatures, and uncover potentially druggable disease pathways.

Methods

We performed bulk RNA-sequencing of LC and collagenous colitis (CC) colonic mucosa from patients with active disease, and healthy controls (n = 4-10 per cohort). Differential gene expression was analyzed by gene-set enrichment and deconvolution analyses to identify pathologically relevant pathways and cells, respectively, altered in LC. Key findings were validated using reverse transcription quantitative PCR and/or immunohistochemistry. Finally, we compared our d

SUBMITTER: Bhardwaj A 

PROVIDER: S-EPMC11250513 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature