A novel prognostic signature related to programmed cell death in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma primarily affects children and adolescents, with current clinical treatments often resulting in poor prognosis. There has been growing evidence linking programmed cell death (PCD) to the occurrence and progression of tumors. This study aims to enhance the accuracy of OS prognosis assessment by identifying PCD-related prognostic risk genes, constructing a PCD-based OS prognostic risk model, and characterizing the function of genes within this model.

Method

We retrieved osteosarcoma patient samples from TARGET and GEO databases, and manually curated literature to summarize 15 forms of programmed cell death. We collated 1621 PCD genes from literature sources as well as databases such as KEGG and GSEA. To construct our model, we integrated ten machine lea

SUBMITTER: Jiang YC 

PROVIDER: S-EPMC11250594 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature