Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database.

ABSTRACT:

Introduction

Despite the established cross-sectional association between alcohol intake and serum urate (SU), its longitudinal association remains unknown. This study aimed to determine whether changes in alcohol intake have a clinically relevant association with SU change.

Method

We conducted retrospective analyses using systematically collected annual medical examination data from October 2012 to October 2022 in a Japanese preventive medicine centre. The exposure was changes in alcohol intake between two consecutive visits. The association of SU changes with alcohol intake changes was estimated by mixed-effect linear regression with adjustment for relevant covariates.

Results

We analysed 63 486 participants (median age, 47.0 years; 55% women; 58.6% regular alcohol d

SUBMITTER: Fukui S 

PROVIDER: S-EPMC11250628 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature