CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case-control study.

ABSTRACT:

Background

Lung cancer, with its high morbidity and mortality, presents a major significant public health challenge. CD147, linked to cancer progression and metastasis, is a promising therapeutic target, including for lung cancer. The genetic variation may influence the expression of the gene and consequently the risk of lung cancer. This study aims to investigate single nucleotide polymorphisms (SNPs) in CD147 to understand their association with the risk of developing lung cancer in the Han Chinese population.

Methods

A hospital-based case-control investigation was conducted, enrolling 700 lung cancer patients and 700 cancer-free controls. TagSNPs were selected using Haploview v4.2, and genotype data from the 1000 Genomes Project database were utilized. The selected SNPs (

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11250716 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature