Distal Immunization and Systemic Cytokines Establish a Transient Immune Alert State in the Intestine.

ABSTRACT: Conventionally, immune responses are studied in the context of inflamed tissues and their corresponding draining lymph nodes (LNs). However, little is known about the effects of systemic inflammatory signals generated during local inflammation on distal tissues and nondraining LNs. Using a mouse model of cutaneous immunization, we found that systemic inflammatory stimuli triggered a rapid and selective distal response in the small intestine and the mesenteric LN (mesLN). This consisted of increased permeability of intestinal blood vessels and lymphatic drainage of bloodborne solutes into the mesLN, enhanced activation and migration of intestinal dendritic cells, as well as amplified T cell responses in the mesLNs to systemic but not orally derived Ags. Mechanistically, we found that the sm

SUBMITTER: Wu Y 

PROVIDER: S-EPMC11250722 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature