Differential gene expression between central and peripheral retinal regions in dogs and comparison with humans.

ABSTRACT: The dog retina contains a central macula-like region, and there are reports of central retinal disorders in dogs with shared genetic etiologies with humans. Defining central/peripheral gene expression profiles may provide insight into the suitability of dogs as models for human disorders. We determined central/peripheral posterior eye gene expression profiles in dogs and interrogated inherited retinal and macular disease-associated genes for differential expression between central and peripheral regions. Bulk tissue RNA sequencing was performed on 8 mm samples of the dog central and superior peripheral regions, sampling retina and retinal pigmented epithelium/choroid separately. Reads were mapped to CanFam3.1, read counts were analyzed to determine significantly differentially expressed ge

SUBMITTER: Salzman MM 

PROVIDER: S-EPMC11250724 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature